منابع مشابه
Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections.
Background Combined immunodeficiencies are marked by inborn errors of T-cell immunity in which the T cells that are present are quantitatively or functionally deficient. Impaired humoral immunity is also common. Patients have severe infections, autoimmunity, or both. The specific molecular, cellular, and clinical features of many types of combined immunodeficiencies remain unknown. Methods We p...
متن کاملDimerization of DOCK2 Is Essential for DOCK2-Mediated Rac Activation and Lymphocyte Migration
The migratory properties of lymphocytes depend on DOCK2, an atypical Rac activator predominantly expressed in hematopoietic cells. Although DOCK2 does not contain the Dbl homology domain typically found in guanine nucleotide exchange factors (GEFs), DOCK2 mediates the GTP-GDP exchange reaction for Rac via its DOCK homology region (DHR)-2 (also known as CZH2 or Docker) domain. DOCK2 DHR-2 domain...
متن کاملMotoring ahead with rodents.
How neural circuits underlie the acquisition and control of learned motor behaviors has traditionally been explored in monkeys and, more recently, songbirds. The development of genetic tools for functional circuit analysis in rodents, the availability of transgenic animals with well characterized phenotypes, and the relative ease with which rats and mice can be trained to perform various motor ...
متن کاملEssential role of Elmo1 in Dock2-dependent lymphocyte migration.
Elmo1 and Elmo2 are highly homologous cytoplasmic adaptor proteins that interact with Dock family guanine nucleotide exchange factors to promote activation of the small GTPase Rac. In T lymphocytes, Dock2 is essential for CCR7- and CXCR4-dependent Rac activation and chemotaxis, but the role of Elmo proteins in regulating Dock2 function in primary T cells is not known. In this article, we show t...
متن کاملFastSLAM with Look-ahead RBPF
In this paper we present an implementation of the Rao-Blackwellised particle filtering (RBPF) with one step look-ahead and apply the algorithm within the domain of agent navigation. Specifically we tackle the simultaneous localization and mapping problem (SLAM), which describes how a agent must concurrently attempt to determine its location and generate a map of the surrounding landmarks. Our i...
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ژورنال
عنوان ژورنال: Blood
سال: 2018
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2018-05-848382